I talked about how Neil deGrasse Tyson gave a performance that was close to a stand-up act. That isn’t quite what he was doing; he gave a very funny lecture about his experience with the Pluto controversy. There are, however, a few people around who do a science-fueled stand-up act.
Brian Malow is a San Francisco based comic who does “Full spectrum, high-energy comedy”. Here’s his best-of video: